GTR2 Works for me under x64 but I have to use a nocd .exe which can be found at nogrip.
As far as I'm aware nocd isn't illegal to use as long as you own the game.
Im pretty sure that GTR2 uses securom, NOT Starforce. GTR2 works fine under Vista 64bit - pretty much anyone i can think of that owns it has got it to work fine with Vista.
GTL and GTR however both use Starforce which means you need to update the drivers or it will stop Vista from booting properly - and of course the game wont run either.