I've got Steam, all of its games, and most of the programs on my computer installed on a secondary drive instead of the main drive. I do have FileStream installed for working directly on my google drive, but that's all separate from my games install drive, which is a physical drive.
Avast updated today, and I'm assuming the update made it over-eager, and when AC CTD'd loading it probably nuked it. A verification got it back, but after another CTD during loading the exe was gone again, and this time I couldn't download it again (Steam wasn't able to access the drive). Uninstalling Avast allowed Steam to download the files again, and since I've gone through a few more CTDs while testing things without losing the exe again.
So, in the end, Avast killed my AC, but for some reason my old ai lines still cause the track to crash. Weird.