No need for in-game AA.Just to add- what I've noticed is you need a slightly different mix of AA for monitor racing compared to VR. On my triples I must use the in-game AA to get rid of the shimmering on the white lines no matter what - and then use enhance setting Nvidia inspector (Antialiasing - transparency supersampling + 4xMSAA) also. VR is different and don't need or use in-game AA.
You need Nvidia profile inspector and set :
Antialiasing compatibility 0x004412C1 (Diablo III)
That goes for all Gmotor 2 games and when you update the GPU driver you have to set it again as it gets deleted.
If you have a RTX type GPU the DL DSR are a real game changer as it is very light on the GPU.
I use DL DSR 2.25 and msaa x2 and sgss x 2 and do not think it can get much better on my monitor.