The first few races will be pretty interesting on this. It seems pretty clear that Mercedes has the best power plant, but who knows how that is going to work out in terms of economy and reliability.
Knowing my luck, I'm sure I will score decently in the first few rounds of pure guessing and start to drop off once I think I know what I'm talking about. Last season I kept thinking Webber was due a win (or a podium at least), but his car kept blowing up (-_-')