Depends. It comes down to physical size of the displays and resulting PPI. Try here:
You'd have to find a combination where the difference in PPI is the same or close enough that you don't object.
I've read the recommendation is to not exceed a difference of 5-10 PPI. From the calculator your proposed sizes should be a close match with ~3 PPI difference, which you may or may not notice in the form of on screen items (e.g.: barriers, curbs, etc) that do not line up from center to left/right. You would also have a >3" variation in physical height to account for and on that front I echo Noahbet's comments re: Radeon drivers as I had the same experience, but since shifted over the NVIDIA.
If it's any value, I used to run a 40" 4k flanked by two 1920x1080 in portrait. It worked, but compromises had to be made. I now run 3 x 32".