The closest right now is probably
Mercedes SSK 1928, or some early-30s cars for the Shift Street mod (specifically the SimRaceWay ports). For the tracks, there are Targa Florio and other long-ass circuits, like
Cannonball Run. I do vaguely feel that Mille-Miglia-like races could and should have a better virtual implementation than the PS1 game (though personally I don't often have the patience for such a run).
(Edit: on further appraisal, Merc '28 seems to have handling and braking that rivals Trans-Am from '69, or modern street cars. The ‘Voiturettes’ from the GP 37 mod probably better represent their time.)
GPLaps and Broadbent have shown Benz Patent-Motorwagen from 1886 for Assetto Corsa, with ~2/3rds hp,
running it particularly on Nordschleife. You can't take some even faintly uphill sections on it in anything like a straight line, instead you need to slalom back and forth.
However, the full endurance-like experience of running 126 km on an early 3 hp car is probably better modeled by a game like Jalopy, where parts regularly fail or fall off, and you need to fix or replace them—including running to a store for that.